Multicellular Feedback Control of a Genetic Toggle-Switch in Microbial Consortia
نویسندگان
چکیده
We describe a multicellular approach to control target cell population endowed with bistable toggle-switch. The idea is engineer synthetic microbial consortium consisting of three different populations. In such consortium, two populations, the Togglers, responding some reference input, can induce switch memory mechanism in third population, Targets, so as activate or deactivate additional functionalities cells. Communication among populations established by orthogonal quorum sensing molecules that are used close feedback loop across design validated via in-silico experiments BSim, realistic agent-based simulator bacterial
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ژورنال
عنوان ژورنال: IEEE control systems letters
سال: 2021
ISSN: ['2475-1456']
DOI: https://doi.org/10.1109/lcsys.2020.3000954